- Title
- The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis
- Creator
- Thakkinstian, Ammarin; McEvoy, Mark; Akahori, Masakazu; Arning, Astrid; Edwards, Albert O.; Seddon, Johanna M.; Attia, John; Chakravarthy, Usha; Chakrabarti, Subhabrata; McKay, Gareth J.; Ryu, Euijung; Silvestri, Giuliana; Kaur, Inderjeet; Francis, Peter; Iwata, Takeshi
- Relation
- American Journal of Epidemiology Vol. 176, Issue 5, p. 361-372
- Publisher Link
- http://dx.doi.org/10.1093/aje/kws031
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2012
- Description
- The authors performed a systematic review of the association of complement component 2(C2)/complement factor B (CFB) gene polymorphisms with age-related macular degeneration (AMD). In total, data from 19 studies published between 2006 and 2011 were pooled for 4 polymorphisms: rs9332739 and rs547154 in the C2 gene and rs4151667 and rs641153 in the CFB gene. Data extraction and assessments for risk of bias were independently performed by 2 reviewers. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Pooled minor allele frequencies for all 4 SNPs were between 4.7% and 9.6% for all polymorphisms, except for an Indian population in which the C allele at rs9332739 was the major allele. For the C2 polymorphisms, the minor C allele at rs9332739 and the minor T allele at rs547154 carried estimated relative risks (odds ratios) of 0.55 (95% confidence interval (CI): 0.46, 0.65) and 0.47 (95% CI: 0.39, 0.57), respectively. For the CFB polymorphisms, the minor A alleles at rs4151667 and rs614153 carried estimated risks of 0.54 (95% CI: 0.45, 0.64) and 0.41 (95% CI: 0.34, 0.51), respectively. These allele effects contributed to an absolute lowering of the risk of all AMD in Caucasian populations by 2.0%-6.0%. This meta-analysis provides a robust estimate of the protective association of C2/CFB with AMD.
- Subject
- complement component factor 2; complement factor B; genetic association studies; genetics; genome; human; macular degeneration; meta-analysis; molecular epidemiology
- Identifier
- http://hdl.handle.net/1959.13/1301914
- Identifier
- uon:20368
- Identifier
- ISSN:0002-9262
- Language
- eng
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